Discovery and Characterisation of 2-Anilino-4-(thiazol-5- yl)pyrimidine Transcriptional CDK Inhibitors as Antican- cer Agents
نویسندگان
چکیده
Cyclacel Limited, Dundee DD1 5JJ, Scotland, UK Present address: School of Pharmacy and Centre for Biomolecular Sciences, University of Nottingham, Nottingham NG7 2RD, UK Present address: Veterinary School, University of Thessaly, Karditsa 43100, Greece Present address: South Carolina College of Pharmacy, University of South Carolina, Columbia, SC 29208, USA *Correspondence: [email protected] (D.G.B), [email protected] (P.M.F)
منابع مشابه
Discovery and characterization of 2-anilino-4- (thiazol-5-yl)pyrimidine transcriptional CDK inhibitors as anticancer agents.
The main difficulty in the development of ATP antagonist kinase inhibitors is target specificity, since the ATP-binding motif is present in many proteins. We introduce a strategy that has allowed us to identify compounds from a kinase inhibitor library that block the cyclin-dependent kinases responsible for regulating transcription, i.e., CDK7 and especially CDK9. The screening cascade employs ...
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تاریخ انتشار 2010